P-174 Outcomes in local gastric cancer resected without neoadjuvant therapy: A descriptive study
نویسندگان
چکیده
Gastric cancer is an aggressive tumor, normally diagnosed at advanced stages and with high mortality rates. Less than 20% of patients are early stages, for them endoscopic therapy or surgery may be a curative option. Correct staging necessary to identify resectable potentially patients. It recommended perform CT scan, ultrasound endoscopy (EUS) exploratory laparoscopy in all >T2 node-positive tumors. However, there understaged before due these procedures not always performed, so they do receive the suitable treatment as neoadjuvant chemotherapy, which has been proven superior better tolerated adjuvant reaching tumor downstaging more surgeries. Guidelines recommend receiving perioperative platinum-based chemotherapy combination fluoropyrimidines docetaxel >IB when possible. In this retrospective unicenter study conducted Catalan Institute Oncology Girona we reviewed local gastric (LGC) who underwent without between 2018 2021. A total 54 were included. 25 defined cT1-2N0 (local tumors) lower, but pathologic stage was reviewed, 16 pT3-T4 disease (+), incorrectly staged. our sample, only 19 had both scan EUS surgery. Of patients, 15 classified tumors, 10 (N+) locally (pT3-T4). case, sensibility 83% specificity 23%, positive negative predictive value 33% 75% respectively. When 100% 81%. There 9 that after staged tumous (stage III IV). 8 indifferenciated tumors (88%), 7 vascular, lymphatic perineural invasion. 3 already relapsed. Understaging common routine clinical practice, probably because needed correct easy imply delay start oncospecific treatment. accuracy serie suboptimal even confounding factor. The procedure lower 0,5, meaning false leading incorrect could have benefit from therapy. conclusion, diagnostic should used, especially it comes undifferentiated Knowing this, unless patient unfit age comorbidities requires emergency surgery, consider incorporating IB higher.
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ژورنال
عنوان ژورنال: Annals of Oncology
سال: 2023
ISSN: ['0923-7534', '1569-8041']
DOI: https://doi.org/10.1016/j.annonc.2023.04.230